Grand rounds are an important teaching tool of medical education, consisting of presenting the medical problems and treatment of a particular patient (or population of patients) to an audience consisting of doctors, residents, and medical students.   Grand rounds help doctors and other healthcare professionals keep up to date in important evolving areas which may be outside of their core practice.
 
Grand rounds have evolved, with most sessions being more like lectures, and with audiences expanding to include research professionals in the academic, government, industry, and advocacy domains.
 
The Grand Rounds featured here, as part of a shared forum of the NIH HCS Collaboratory and PCORnet, provide insightful updates focused on innovative, alternative, streamlined approaches to the conduct of pragmatic clinical trials.

To subscribe to our Grand Rounds mailing list, please email us at nih-collaboratory@dm.duke.edu.
  
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FDA and Pragmatic Clinical Trials of Marketed Medical ProductsAnderson, Monique7/15/2016Duke University School of Medicine; Duke Clinical Research InstituteSlidesGrand-Rounds-07-15-16Clinical research; Comparative effectiveness research; Cluster randomized trial; Informed consent and human subjects protection; Regulatory issues
Mobile Health Data for Clinical and Health Systems ResearchSim, Ida7/8/2016University of California, San FranciscoSlidesGrand-Rounds-07-08-16Clinical research; Data standards and interoperability; Patient-reported outcomes; Translational research
Recommendations for Recruitment: Moving Recruitment Planning Upstream To Reduce Barriers to ParticipationMassett, Holly; McKee, Kelly6/24/2016Clinical Trials Transformation Initiative (CTTI)SlidesGrand-Rounds-06-24-16Clinical research; Informed consent and human subjects protection; Patient engagement; Patient-centered research; Stakeholder engagement; Study design
Oversight on the Borderline: Quality Improvement and Pragmatic ResearchFinkelstein, Jonathan6/17/2016Harvard Medical SchoolSlidesGrand-Rounds-06-17-16Clinical research; Informed consent and human subjects protection; Learning healthcare system; Regulatory issues; Research ethics
Pragmatic Trials in Dialysis: What’s Next After the TiME Trial?Dember, Laura6/10/2016University of PennsylvaniaSlidesGrand-Rounds-06-10-16Comparative effectiveness research; Pragmatic clinical trial; Provider-health system interactions
CTSA Trial Innovation Network: Early Vision & GoalsShah, Monica6/3/2016National Center for Advancing Translational Sciences (NCATS)SlidesGrand-Rounds-06-03-16Clinical research; Implementation; Network policies & governance; Translational research
Altered Informed Consent in Pragmatic Clinical TrialsMcKinney, Ross5/20/2016Duke UniversitySlidesGrand-Rounds-05-20-16Clinical research; Informed consent and human subjects protection; Patient engagement; Research ethics; Regulatory issues; Pragmatic clinical trial
ABATE Infection Trial: Backstage TourHuang, Susan; Septimus, Ed5/13/2016University of California, Irvine; Hospital Corporation of America (HCA) Clinical Services GroupSlidesGrand-Rounds-05-13-16Cluster randomized trial; Comparative effectiveness research; Pragmatic clinical trial; Provider-health system interactions; Study design
Clinician Engagement in the NIH Collaboratory and BeyondMoloney, Rachael; Tunis, Sean; Tambor, Ellen5/6/2016Center for Medical Technology Policy (CMTP)SlidesGrand-Rounds-05-06-16Clinical research; Provider-health system interactions; Stakeholder engagement
PCORnet and CTSA Network: Synergizing National InitiativesCurtis, Lesley; Chandler, Redonna; Fleurence, Rachael; Marsolo, Keith; Shah, Monica; Gersing, Ken4/29/2016Duke Clinical Research Institute; Patient-Centered Outcomes Research Institute (PCORI); PCORnet; National Center for Advancing Translational Sciences (NCATS); Cincinnati Children's HospitalSlidesGrand-Rounds-04-29-16Clinical research; Data sharing; Data quality; Data standards and interoperability; Distributed research network; Patient-centered research; PCORnet; Research dissemination; Translational research
Challenges and Opportunities for Using Common PRO Measures in Comparative Effectiveness ResearchSimon, Gregory; Cella, David; Laws, Reesa4/22/2016Northwestern University; Group Health Research Institute; Kaiser Permanente Center for Health ResearchSlidesGrand-Rounds-04-22-16Comparative effectiveness research; Data standards and interoperability; Patient-reported outcomes
Considerations in the Evaluation and Determination of Minimal Risk in Research StudiesLantos, John4/15/2016Children's Mercy HospitalSlidesGrand-Rounds-04-15-16Clinical research; Cluster randomized trial; Comparative effectiveness research; Informed consent and human subjects protection; Research ethics; Study design; Regulatory issues; Learning healthcare system
The Trauma Survivors Outcomes & Support (TSOS) Pragmatic Trial Targeting PTSD and Comorbidity: Design and Early ImplementationZatzick, Douglas; Darnell, Doyanne4/8/2016University of WashingtonSlidesGrand-Rounds-04-08-16Cluster randomized trial; Implementation; Pragmatic clinical trial; Study design
Leveraging EHR Data to Evaluate Sepsis GuidelinesWestra, Bonnie4/1/2016University of MinnesotaSlidesGrand-Rounds-04-01-16Clinical research; Electronic health records; Informatics
Ethical Responsibilities Toward Indirect and Collateral Participants in Pragmatic Clinical TrialsSmalley, Jaye Bea3/18/2016Patient-Centered Outcomes Research Institute (PCORI)SlidesGrand-Rounds-03-18-16Cluster randomized trial; Informed consent and human subjects protection; Patient engagement; Stakeholder engagement; Research ethics; Pragmatic clinical trial; Study design
Uses of the NIH Collaboratory Distributed Research Network (DRN)Brown, Jeffrey3/11/2016Harvard Pilgrim Health Care InstituteSlidesGrand-Rounds-03-11-16Distributed research network; Electronic health records; Network policies & governance; Data standards and interoperability
Patient-Focused Benefit-Risk AssessmentLevitan, Bennett3/4/2016Janssen Research and DevelopmentSlidesGrand-Rounds-03-04-16Clinical research; Patient-centered research; Study design
Pragmatic Trials in Nursing Homes: Benefits of a Uniform Minimal Clinical Data Set Linked to Medicare DataMor, Vincent2/26/2016Brown University School of Public HealthSlidesGrand-Rounds-02-26-16Data standards and interoperability; Electronic health records; Pragmatic clinical trial; Cluster randomized trial
Harms, Benefits, and the Nature of Interventions in Pragmatic Clinical TrialsAli, Joseph2/19/2016Johns Hopkins Berman Institute of BioethicsSlidesGrand-Rounds-02-19-16Informed consent and human subjects protection; Pragmatic clinical trial; Provider-health system interactions; Research ethics
Salford Lung Study: Lessons LearnedCollier, Sue; Davis, Kourtney2/12/2016GSKSlidesGrand-Rounds-02-12-16Data quality; Electronic health records; Pragmatic clinical trial; Study design
Developing a Participant-Centric Consent Process for ADAPTABLEBeskow, Laura2/5/2016Duke University School of Medicine; PCORnetSlidesGrand-Rounds-02-05-16Patient engagement; Patient-centered research; Learning healthcare system; Informed consent and human subjects protection; PCORnet; Pragmatic clinical trial; Study design
Patient Compensation: PCORI's Compensation Framework—Considerations and Practices from the FieldJohnson, Lorraine; Schrandt, Suzanne; Smalley, Jaye Bea1/29/2016LymeDisease.org; Patient-Centered Outcomes Research Institute (PCORI)SlidesGrand-Rounds-01-29-16Clinical research; Patient engagement; Stakeholder engagement; Study design
Use of PRECIS-2 Ratings in the NIH Health Care Systems Research CollaboratoryNeta, Gila; Johnson, Karin1/22/2016Group Health Research Institute; National Cancer Institute (NCI)SlidesGrand-Rounds-01-22-16Pragmatic clinical trial; Study design
Harmonization and Streamlining of Research Oversight for Pragmatic Clinical TrialsO'Rourke, Pearl1/15/2016Partners HealthCareSlidesGrand-Rounds-01-15-16Informed consent and human subjects protection; Pragmatic clinical trial
The Clinical Trials Transformation Initiative's Informed Consent Project: Recommendations and ResourcesLentz, Jennifer; Perlmutter, Jane1/8/2016Clinical Trials Transformation Initiative (CTTI)SlidesGrand-Rounds-01-08-16Informed consent and human subjects protection; Research ethics
The Ethics and Regulatory Landscape of Including Vulnerable Populations in Pragmatic Clinical TrialsWelch, Mary Jane12/18/2015Rush UniversitySlidesGrand-Rounds-12-18-15Pragmatic clinical trial; Research ethics; Informed consent and human subjects protection
Effective Engagement with Patient Groups Around Clinical TrialsSelig, Wendy; Weir, Scott12/11/2015Clinical Trials Transformation Initiative (CTTI)SlidesGrand-Rounds-12-11-15Clinical research; Patient engagement; Stakeholder engagement; Research dissemination
The Precision Medicine Initiative® Cohort Program: Research as a Team SportPatrick-Lake, Bray; Denny, Joshua; Briggs, Josephine12/4/2015Clinical Trials Transformation Initiative (CTTI); National Institutes of Health (NIH)SlidesGrand-Rounds-12-04-15Data sharing; Clinical research; Patient engagement; Stakeholder engagement
Gatekeepers for Pragmatic Clinical TrialsWhicher, Danielle11/20/2015Patient-Centered Outcomes Research Institute (PCORI)SlidesGrand-Rounds-11-20-15Cluster randomized trial; Implementation; Pragmatic clinical trial; Stakeholder engagement
Lemons or Peaches: What Trials Should Be?Lauer, Michael11/13/2015National Institutes of Health (NIH)SlidesGrand-Rounds-11-13-15Clinical research
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