Grand rounds are an important teaching tool of medical education, consisting of presenting the medical problems and treatment of a particular patient (or population of patients) to an audience consisting of doctors, residents, and medical students.   Grand rounds help doctors and other healthcare professionals keep up to date in important evolving areas which may be outside of their core practice.
 
Grand rounds have evolved, with most sessions being more like lectures, and with audiences expanding to include research professionals in the academic, government, industry, and advocacy domains.
 
The Grand Rounds featured here, as part of a shared forum of the NIH HCS Collaboratory and PCORnet, provide insightful updates focused on innovative, alternative, streamlined approaches to the conduct of pragmatic clinical trials.

To subscribe to our Grand Rounds mailing list, please email us at nih-collaboratory@dm.duke.edu.
  
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Lessons Learned from the NIH Collaboratory Biostatistics and Design CoreCook, Andrea12/2/2016University of Washington; Group Health Research InstituteSlidesGrand-Rounds-12-02-16NewClinical research; Cluster randomized trial; Data analysis; Pragmatic clinical trial; Study design; Biostatistics
Lumbar Imaging with Reporting of Epidemiology (LIRE): The Beginning of the End (or The End of the Beginning?)Jarvik, Jeffrey; Heagerty, Patrick11/18/2016University of WashingtonSlidesGrand-Rounds-11-18-16Clinical research; Cluster randomized trial; Data analysis; Informatics; Electronic health records; Stakeholder engagement; Study design
Recommendations from the Clinical Trials Transformation Initiative’s Data Monitoring Committee ProjectBain, Ray; Calis, Karim; DeMets, Dave11/11/2016Clinical Trials Transformation Initiative (CTTI)SlidesGrand-Rounds-11-11-16Clinical research; Data quality; Biostatistics; Informatics; Research ethics; Study design
Colorectal Cancer Screening in Primary Care: A Focus on STOP CRCCoronado, Gloria; Green, Beverly11/4/2016Kaiser Permanente Center for Health Research; Group Health Research InstituteSlidesGrand-Rounds-11-04-16Clinical research; Cluster randomized trial; Comparative effectiveness research; Electronic health records; Pragmatic clinical trial; Research dissemination; Study design; Implementation
Research on Medical Practices: Willingness to Participate and the Investigational MisconceptionMagnus, David; Wilfond, Benjamin10/28/2016Stanford University; University of WashingtonSlidesGrand-Rounds-10-28-16Clinical research; Comparative effectiveness research; Learning healthcare system; Informed consent and human subjects protection; Pragmatic clinical trial; Research ethics; Study design
Demographics, Subgroup Analyses, and Statistical Considerations in Cluster-Randomized TrialsAnderson, Monique10/21/2016Duke Clinical Research Institute; Duke University School of MedicineSlidesGrand-Rounds-10-21-16Cluster randomized trial; Data analysis; Electronic health records; Pragmatic clinical trial; Research dissemination
Multidisciplinary Chronic Pain Management in Primary Care: Paradox or Paradigm?DeBar, Lynn; McMullen, Carmit; Elder, Charles10/14/2016Kaiser Permanente Center for Health ResearchSlidesGrand-Rounds-10-14-16Clinical research; Cluster randomized trial; Electronic health records; Pragmatic clinical trial; Provider-health system interactions
Chlorthalidone versus Hydrochlorothiazide: A New Kind of VA Cooperative StudyLederle, Frank10/7/2016University of Minnesota; Department of Veterans AffairsSlidesGrand-Rounds-10-07-16Clinical research; Comparative effectiveness research; Electronic health records; Pragmatic clinical trial; Provider-health system interactions; Research ethics
Dig If You Will the Picture of the NIH CollaboratoryCurtis, Lesley; Hernandez, Adrian; Weinfurt, Kevin9/30/2016Duke Clinical Research Institute; Duke University School of MedicineSlidesGrand-Rounds-09-30-16Clinical research; Learning healthcare system; Provider-health system interactions; Research dissemination; Pragmatic clinical trial; Implementation
ICD-Pieces: Early Implementation and ProgressVazquez, Miguel; Oliver, George9/23/2016UT Southwestern Medical CenterSlidesGrand-Rounds-09-23-16Cluster randomized trial; Comparative effectiveness research; Informatics; Electronic health records; Electronic phenotypes; Stakeholder engagement; Pragmatic clinical trial; Provider-health system interactions
PCORnet Building TrustworthinessDavid, Jennie; Flentje, Annesa; Terry, Sharon; Williams, Neely9/16/2016Genetic Alliance; Community Partners Network; Drexel University; University of California, San FranciscoSlidesGrand-Rounds-09-16-16Clinical research; Patient engagement; Patient-centered research; Research ethics; Stakeholder engagement; Research dissemination
Million Veteran Program: A Mega-Cohort Within a Healthcare SystemGaziano, Michael9/9/2016Harvard Medical School; Department of Veterans AffairsSlidesGrand-Rounds-09-09-16Clinical research; Data standards and interoperability; Data analysis; Electronic health records; Electronic phenotypes; Registries and biorepositories; Patient engagement
Updates from the Phenotypes, Data Standards, and Data Quality Core of the NIH HCS Research CollaboratoryRichesson, Rachel8/26/2016Duke University School of Nursing; Duke Clinical Research InstituteSlidesGrand-Rounds-08-26-16Clinical research; Data quality; Data standards and interoperability; Electronic phenotypes; Learning healthcare system; Electronic health records
Privacy and Confidentiality in Pragmatic Clinical TrialsRubel, Alan8/19/2016University of Wisconsin, MadisonSlidesGrand-Rounds-08-19-16Clinical research; Data privacy & security; Electronic health records; Informed consent and human subjects protection; Research ethics; Pragmatic clinical trial; Learning healthcare system
Sharing Data: Methods to Increase Data Sharing and Improve Human HealthGibson, Michael; Patel, Manesh8/12/2016Duke University School of Medicine; Harvard Medical School; Duke University Health SystemSlidesGrand-Rounds-08-12-16Clinical research; Data sharing
Embedded Pragmatic Trials: Triumphs and TribulationsRamsberg, Joakim8/5/2016Harvard Pilgrim Health Care InstituteSlidesGrand-Rounds-08-05-16Clinical research; Cluster randomized trial; Electronic health records; Pragmatic clinical trial; Study design; Learning healthcare system
Accessing PCORnet's Data and Network ResourcesForrest, Christopher7/29/2016Children's Hospital of Philadelphia; PCORnetSlidesGrand-Rounds-07-29-16Clinical research; Data privacy & security; Distributed research network; Learning healthcare system; Patient-centered research; Pragmatic clinical trial; PCORnet; Stakeholder engagement
Preparing for a Pragmatic Influenza Vaccine Clinical Trial: A One-shot DealSolomon, Scott; Vardeny, Orly7/22/2016Harvard Medical School; University of Wisconsin, Madison; National Heart, Lung, and Blood Institute (NHLBI)SlidesGrand-Rounds-07-22-16Comparative effectiveness research; Pragmatic clinical trial; Study design
FDA and Pragmatic Clinical Trials of Marketed Medical ProductsAnderson, Monique7/15/2016Duke University School of Medicine; Duke Clinical Research InstituteSlidesGrand-Rounds-07-15-16Clinical research; Comparative effectiveness research; Cluster randomized trial; Informed consent and human subjects protection; Regulatory issues
Mobile Health Data for Clinical and Health Systems ResearchSim, Ida7/8/2016University of California, San FranciscoSlidesGrand-Rounds-07-08-16Clinical research; Data standards and interoperability; Patient-reported outcomes; Translational research
Recommendations for Recruitment: Moving Recruitment Planning Upstream To Reduce Barriers to ParticipationMassett, Holly; McKee, Kelly6/24/2016Clinical Trials Transformation Initiative (CTTI)SlidesGrand-Rounds-06-24-16Clinical research; Informed consent and human subjects protection; Patient engagement; Patient-centered research; Stakeholder engagement; Study design
Oversight on the Borderline: Quality Improvement and Pragmatic ResearchFinkelstein, Jonathan6/17/2016Harvard Medical SchoolSlidesGrand-Rounds-06-17-16Clinical research; Informed consent and human subjects protection; Learning healthcare system; Regulatory issues; Research ethics
Pragmatic Trials in Dialysis: What’s Next After the TiME Trial?Dember, Laura6/10/2016University of PennsylvaniaSlidesGrand-Rounds-06-10-16Comparative effectiveness research; Pragmatic clinical trial; Provider-health system interactions
CTSA Trial Innovation Network: Early Vision & GoalsShah, Monica6/3/2016National Center for Advancing Translational Sciences (NCATS)SlidesGrand-Rounds-06-03-16Clinical research; Implementation; Network policies & governance; Translational research
Altered Informed Consent in Pragmatic Clinical TrialsMcKinney, Ross5/20/2016Duke UniversitySlidesGrand-Rounds-05-20-16Clinical research; Informed consent and human subjects protection; Patient engagement; Research ethics; Regulatory issues; Pragmatic clinical trial
ABATE Infection Trial: Backstage TourHuang, Susan; Septimus, Ed5/13/2016University of California, Irvine; Hospital Corporation of America (HCA) Clinical Services GroupSlidesGrand-Rounds-05-13-16Cluster randomized trial; Comparative effectiveness research; Pragmatic clinical trial; Provider-health system interactions; Study design
Clinician Engagement in the NIH Collaboratory and BeyondMoloney, Rachael; Tunis, Sean; Tambor, Ellen5/6/2016Center for Medical Technology Policy (CMTP)SlidesGrand-Rounds-05-06-16Clinical research; Provider-health system interactions; Stakeholder engagement
PCORnet and CTSA Network: Synergizing National InitiativesCurtis, Lesley; Chandler, Redonna; Fleurence, Rachael; Marsolo, Keith; Shah, Monica; Gersing, Ken4/29/2016Duke Clinical Research Institute; Patient-Centered Outcomes Research Institute (PCORI); PCORnet; National Center for Advancing Translational Sciences (NCATS); Cincinnati Children's HospitalSlidesGrand-Rounds-04-29-16Clinical research; Data sharing; Data quality; Data standards and interoperability; Distributed research network; Patient-centered research; PCORnet; Research dissemination; Translational research
Challenges and Opportunities for Using Common PRO Measures in Comparative Effectiveness ResearchSimon, Gregory; Cella, David; Laws, Reesa4/22/2016Northwestern University; Group Health Research Institute; Kaiser Permanente Center for Health ResearchSlidesGrand-Rounds-04-22-16Comparative effectiveness research; Data standards and interoperability; Patient-reported outcomes
Considerations in the Evaluation and Determination of Minimal Risk in Research StudiesLantos, John4/15/2016Children's Mercy HospitalSlidesGrand-Rounds-04-15-16Clinical research; Cluster randomized trial; Comparative effectiveness research; Informed consent and human subjects protection; Research ethics; Study design; Regulatory issues; Learning healthcare system
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