Grand rounds are an important teaching tool of medical education, consisting of presenting the medical problems and treatment of a particular patient (or population of patients) to an audience consisting of doctors, residents, and medical students.   Grand rounds help doctors and other healthcare professionals keep up to date in important evolving areas which may be outside of their core practice.
Grand rounds have evolved, with most sessions being more like lectures, and with audiences expanding to include research professionals in the academic, government, industry, and advocacy domains.
The Grand Rounds featured here, as part of a shared forum of the NIH HCS Collaboratory and PCORnet, provide insightful updates focused on innovative, alternative, streamlined approaches to the conduct of pragmatic clinical trials.

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Collaboratory Affiliation
Topic Index
Challenges and Opportunities for Using Common PRO Measures in Comparative Effectiveness ResearchSimon, Gregory; Cella, David; Laws, Reesa4/22/2016Northwestern University; Group Health Research Institute; Kaiser Permanente Center for Health ResearchSlidesGrand-Rounds-04-22-16Comparative effectiveness research; Data standards and interoperability; Patient-reported outcomes
Considerations in the Evaluation and Determination of Minimal Risk in Research StudiesLantos, John4/15/2016Children's Mercy HospitalSlidesGrand-Rounds-04-15-16Clinical research; Cluster randomized trial; Comparative effectiveness research; Informed consent and human subjects protection; Research ethics; Study design; Regulatory issues; Learning healthcare system
The Trauma Survivors Outcomes & Support (TSOS) Pragmatic Trial Targeting PTSD and Comorbidity: Design and Early ImplementationZatzick, Douglas; Darnell, Doyanne4/8/2016University of WashingtonSlidesGrand-Rounds-04-08-16Cluster randomized trial; Implementation; Pragmatic clinical trial; Study design
Leveraging EHR Data to Evaluate Sepsis GuidelinesWestra, Bonnie4/1/2016University of MinnesotaSlidesGrand-Rounds-04-01-16Clinical research; Electronic health records; Informatics
Ethical Responsibilities Toward Indirect and Collateral Participants in Pragmatic Clinical TrialsSmalley, Jaye Bea3/18/2016Patient-Centered Outcomes Research Institute (PCORI)SlidesGrand-Rounds-03-18-16Cluster randomized trial; Informed consent and human subjects protection; Patient engagement; Stakeholder engagement; Research ethics; Pragmatic clinical trial; Study design
Uses of the NIH Collaboratory Distributed Research Network (DRN)Brown, Jeffrey3/11/2016Harvard Pilgrim Health Care InstituteSlidesGrand-Rounds-03-11-16Distributed research network; Electronic health records; Network policies & governance; Data standards and interoperability
Patient-Focused Benefit-Risk AssessmentLevitan, Bennett3/4/2016Janssen Research and DevelopmentSlidesGrand-Rounds-03-04-16Clinical research; Patient-centered research; Study design
Pragmatic Trials in Nursing Homes: Benefits of a Uniform Minimal Clinical Data Set Linked to Medicare DataMor, Vincent2/26/2016Brown University School of Public HealthSlidesGrand-Rounds-02-26-16Data standards and interoperability; Electronic health records; Pragmatic clinical trial; Cluster randomized trial
Harms, Benefits, and the Nature of Interventions in Pragmatic Clinical TrialsAli, Joseph2/19/2016Johns Hopkins Berman Institute of BioethicsSlidesGrand-Rounds-02-19-16Informed consent and human subjects protection; Pragmatic clinical trial; Provider-health system interactions; Research ethics
Salford Lung Study: Lessons LearnedCollier, Sue; Davis, Kourtney2/12/2016GSKSlidesGrand-Rounds-02-12-16Data quality; Electronic health records; Pragmatic clinical trial; Study design
Developing a Participant-Centric Consent Process for ADAPTABLEBeskow, Laura2/5/2016Duke University School of Medicine; PCORnetSlidesGrand-Rounds-02-05-16Patient engagement; Patient-centered research; Learning healthcare system; Informed consent and human subjects protection; PCORnet; Pragmatic clinical trial; Study design
Patient Compensation: PCORI's Compensation Framework—Considerations and Practices from the FieldJohnson, Lorraine; Schrandt, Suzanne; Smalley, Jaye Bea1/29/; Patient-Centered Outcomes Research Institute (PCORI)SlidesGrand-Rounds-01-29-16Clinical research; Patient engagement; Stakeholder engagement; Study design
Use of PRECIS-2 Ratings in the NIH Health Care Systems Research CollaboratoryNeta, Gila; Johnson, Karin1/22/2016Group Health Research Institute; National Cancer Institute (NCI)SlidesGrand-Rounds-01-22-16Pragmatic clinical trial; Study design
Harmonization and Streamlining of Research Oversight for Pragmatic Clinical TrialsO'Rourke, Pearl1/15/2016Partners HealthCareSlidesGrand-Rounds-01-15-16Informed consent and human subjects protection; Pragmatic clinical trial
The Clinical Trials Transformation Initiative's Informed Consent Project: Recommendations and ResourcesLentz, Jennifer; Perlmutter, Jane1/8/2016Clinical Trials Transformation Initiative (CTTI)SlidesGrand-Rounds-01-08-16Informed consent and human subjects protection; Research ethics
The Ethics and Regulatory Landscape of Including Vulnerable Populations in Pragmatic Clinical TrialsWelch, Mary Jane12/18/2015Rush UniversitySlidesGrand-Rounds-12-18-15Pragmatic clinical trial; Research ethics; Informed consent and human subjects protection
Effective Engagement with Patient Groups Around Clinical TrialsSelig, Wendy; Weir, Scott12/11/2015Clinical Trials Transformation Initiative (CTTI)SlidesGrand-Rounds-12-11-15Clinical research; Patient engagement; Stakeholder engagement; Research dissemination
The Precision Medicine Initiative® Cohort Program: Research as a Team SportPatrick-Lake, Bray; Denny, Joshua; Briggs, Josephine12/4/2015Clinical Trials Transformation Initiative (CTTI); National Institutes of Health (NIH)SlidesGrand-Rounds-12-04-15Data sharing; Clinical research; Patient engagement; Stakeholder engagement
Gatekeepers for Pragmatic Clinical TrialsWhicher, Danielle11/20/2015Patient-Centered Outcomes Research Institute (PCORI)SlidesGrand-Rounds-11-20-15Cluster randomized trial; Implementation; Pragmatic clinical trial; Stakeholder engagement
Lemons or Peaches: What Trials Should Be?Lauer, Michael11/13/2015National Institutes of Health (NIH)SlidesGrand-Rounds-11-13-15Clinical research
Lumbar Imaging with Reporting of Epidemiology (LIRE): Lessons LearnedJarvik, Jeffrey11/6/2015University of WashingtonSlidesGrand-Rounds-11-06-15Clinical research; Data quality; Provider-health system interactions
Prospective Registry-based Randomized Clinical Trials—A New Concept for Clinical ResearchJames, Stefan10/30/2015Uppsala UniversitySlidesGrand-Rounds-10-30-15Clinical research; Registries and biorepositories; Study design
Proposed Revisions to the Common RuleHudson, Kathy10/23/2015National Institutes of Health (NIH)SlidesGrand-Rounds-10-23-15Clinical research; Informed consent and human subjects protection; Research ethics
Data Monitoring Committees for Pragmatic Clinical TrialsEllenberg, Susan10/16/2015University of PennsylvaniaSlidesGrand-Rounds-10-16-15Biostatistics; Cluster randomized trial; Pragmatic clinical trial; Research ethics
Diffusion, Dissemination, and Implementation: What is the Difference?Parchman, Michael10/9/2015Group Health Research InstituteSlidesGrand-Rounds-10-09-15Implementation; Research dissemination; Translational research
Stepped-Wedge Cluster-Randomized Trial Design: Opportunities for Implementation Research and Practical Challenges of Its ApplicationAllen, Larry10/2/2015University of ColoradoSlidesGrand-Rounds-10-02-15Clinical research; Cluster randomized trial; Implementation; Study design
Ethical and Regulatory Issues in Pragmatic Clinical Trials: Introducing a Special Series in Clinical TrialsSugarman, Jeremy9/25/2015Johns Hopkins Berman Institute of BioethicsSlidesGrand-Rounds-09-25-15Cluster randomized trial; Pragmatic clinical trial; Informed consent and human subjects protection; Research ethics; Regulatory issues
Year 3 of the NIH Collaboratory: Reflections, Progress, and Looking ForwardHernandez, Adrian; Weinfurt, Kevin; Curtis, Lesley9/18/2015Duke Clinical Research Institute; Duke University School of Medicine; National Institutes of Health (NIH)SlidesGrand-Rounds-09-18-15Implementation; Pragmatic clinical trial; Stakeholder engagement; Clinical research
Patient Engagement in Governance and Research Prioritization for a PCORnet Patient-Powered Research NetworkMerkel, Peter9/11/2015University of Michigan Health System; University of Pennsylvania; PCORnet; Patient-Centered Outcomes Research Institute (PCORI); Vasculitis FoundationSlidesGrand-Rounds-09-11-15Clinical research; Network policies & governance; Patient engagement; Patient-centered research; PCORnet
Addressing an Achilles Heel of PCTs: Missing Race and Ethnicity Data in Electronic Health RecordsAnderson, Monique8/28/2015Duke Clinical Research Institute; Duke University School of MedicineSlidesGrand-Rounds-08-28-15Electronic health records; Pragmatic clinical trial; Race and ethnicity
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